Journal article
Efficacy of User Self-Led and Human-Supported Digital Health Interventions for People With Schizophrenia: A Systematic Review and Meta-Analysis
U Arnautovska, M Trott, KJ Vitangcol, A Milton, E Brown, N Warren, S Leucht, J Firth, D Siskind
Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2025
Abstract
Background Digital health interventions (DHIs) may enable low cost, scalable improvements in the quality of care for adults with schizophrenia. Given the fast-growing number of studies using these tools, this review aimed to assess the efficacy and feasibility of randomized controlled trials (RCTs) of DHIs among people with schizophrenia, focusing on human support. Design A systematic search of PubMed, Embase, PsycINFO, CINAHL, Web of Science, and Cochrane databases was conducted in January 2024 to identify relevant RCTs. Random effects meta-analyses were undertaken to evaluate the effects on psychosis symptoms, cognition, and other health-related outcomes. Results Twenty-six RCTs (n = 2481 ..
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Grants
Awarded by National Institute on Handicapped Research
Funding Acknowledgements
We sincerely thank the medical students and psychiatry trainees, James Vaissiere, Harriet Nwachukwu, and Kenta Sen, who assisted in the initial stages of screening and data extraction. A special thanks goes also to Mark Chatfield for helpful advice on data extraction and to Namal Balasooriya for his assistance in the preliminary stages of data analysis. J.F. is supported by a UK Research and Innovation Future Leaders Fellowship (MR/Y033876/1) and the NIHR Manchester Biomedical Research Centre (NIHR203308). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. JF has received honoraria, consultancy and/or advisory fees from Atheneum, Informa, Bayer, HedoniaUSA, Strive Coaching, Angelini, ParachuteBH, and the Richmond Foundation, independent of this work. A.M. is supported partially by the Australian Government through the Australian Research Council's Centre of Excellence for Children and Families over the Life Course (Project ID CE200100025), the Medical Research Future Fund Clinician Researchers Applied Research in Health (Project ID: MRF2032279), and an NHMRC Targeted Call for Research for Improving